GAD67 (GAD1) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI5D8]
CAT#: TA500330AM
Anti-GAD1 (GAD67) mouse monoclonal antibody, clone OTI5D8 (formerly 5D8), Biotinylated
Conjugation: Unconjugated HRP
USD 200.00
USD 867.00
USD 436.00
Specifications
Product Data | |
Clone Name | OTI5D8 |
Applications | IHC, IP, WB |
Recommended Dilution | WB: 1:200 - 1:1000, IHC: 1:50, IP: 4ug/mL |
Reactivities | Human, Mouse, Rat |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Full-length protein expressed in 293T cell transfected with human GAD1 expression vector |
Formulation | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
Concentration | 0.5 mg/ml |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Biotin |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 66.9 kDa |
Gene Name | glutamate decarboxylase 1 |
Database Link | |
Background | This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. |
Synonyms | CPSQ1; DEE89; GAD; SCP |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Alanine, aspartate and glutamate metabolism, beta-Alanine metabolism, Butanoate metabolism, Metabolic pathways, Taurine and hypotaurine metabolism, Type I diabetes mellitus |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Antibody Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
CF500330 | Carrier-free (BSA/glycerol-free) GAD1 mouse monoclonal antibody, clone OTI5D8 (formerly 5D8) |
USD 600.00 |
|
TA500330 | Anti-GAD1 (GAD67) mouse monoclonal antibody, clone OTI5D8 (formerly 5D8) |
USD 447.00 |
|
TA500330BM | Anti-GAD1 (GAD67) mouse monoclonal antibody, clone OTI5D8 (formerly 5D8), HRP conjugated |
USD 509.00 |
|
TA500330S | Anti-GAD1 (GAD67) mouse monoclonal antibody, clone OTI5D8 (formerly 5D8) |
USD 200.00 |
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