Phospho-Phospholipase C gamma 1 (PLCG1) Rabbit Polyclonal Antibody

CAT#: TA420072

Phospho-PLC gamma 1 (PLCG1)-Y783 Rabbit mAb

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB,1:1000 - 1:5000
• Reactivities: Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic phosphorylated peptide around Y783 of human Phospho-PLC gamma 1 (PLCG1)-Y783 (NP_877963.1).
• Formulation: Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20℃. Avoid freeze / thaw cycles.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 149kDa - Observed MW: 155kDa
• Gene Name: phospholipase C gamma 1
• Database Link:
  UniProt ID P19174
• Background: The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.
• Synonyms: NCKAP3; PLC-II; PLC1; PLC148; PLCgamma1