CD147 (BSG) Rabbit Polyclonal Antibody

CAT#: TA392471

CD147 polyclonal antibody

Product Images

Western blot (WB) analysis of CD147 polyclonal antibody at 1:5000 dilution Lane1:A375 cell membrane lysate(10ug) Lane2:SK-OVCAR3 cell membrane lysate(4ug)

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  Western blot (WB) analysis of CD147 polyclonal antibody at 1:2000 dilution Lane1:EC9706 cell membrane lysate(25ug) Lane2:A549 cell membrane lysate(25ug)

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:2000~1:5000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human CD147.
• Specificity: CD147 polyclonal antibody detects endogenous levels of CD147 protein.
• Formulation: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
• Concentration: 1mg/ml
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
• Stability: 1 year
• Predicted Protein Size: ~ 42 kDa
• Gene Name: basigin (Ok blood group)
• Database Link:
  Entrez Gene 682 Human
  UniProt ID P35613
• Background: Basigin (EMMPRIN, CD147) is a type I integral membrane receptor protein belonging to the immunoglobulin superfamily. Basigin is a glycosylated protein with four known isoforms, of which isoform 2 is the most abundantly expressed. Multiple functions have been ascribed to Basigin; foremost among these is stimulating the secretion of extracellular matrix metalloproteinases by adjacent fibroblasts, a function which has been implicated in promoting tumor progression. Research studies have shown that Basigin is overexpressed by many tumor cells, and its expression level may correlate with tumor malignancy. A recent study identified the BASIGIN gene as a regulatory target of Slug, suggesting a role for Basigin in the process of epithelial-mesenchymal transition. Basigin has also been identified as a marker for a subset of highly suppressive regulatory T cells, and as an obligate receptor for the malarial parasite Plasmodium falciparum on human erythrocytes.
• Synonyms: 5F7; Basigin; BSG; CD147; Collagenase stimulatory factor; EMMPRIN; Extracellular matrix metalloproteinase inducer; HAb18G; Hepatoma-associated antigen; Leukocyte activation antigen M6; OK blood group antigen; TCSF; Tumor cell-derived collagenase stimulatory factor; UNQ6505/PRO21383
• Note: For research use only, not for use in diagnostic procedure.