MAPKAP Kinase 3 (MAPKAPK3) Rabbit Polyclonal Antibody

CAT#: TA370884

MAPKAPK3 rabbit polyclonal antibody

Product Images

Gel: 8%SDS-PAGE Lysate: 40 μg Lane 1-2: HT-29 and HepG2 cell lysates Primary antibody: TA370884 (MAPKAPK3 Antibody) at dilution 1/800 Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution Exposure time: 1 minute

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  Immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using TA370884 (MAPKAPK3 Antibody) at dilution 1/95 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using TA370884 (MAPKAPK3 Antibody) at dilution 1/95, treated with fusion protein. (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human brain tissue using TA370884 (MAPKAPK3 Antibody) at dilution 1/95 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human brain tissue using TA370884 (MAPKAPK3 Antibody) at dilution 1/95, treated with fusion protein. (Original magnification: ×200)

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Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 500-2000
  WB positive control: HT-29 and HepG2 cell lysates
  IHC: 100-300
  Positive control: Human colorectal cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein of human MAPKAPK3
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C.
• Stability: 1 year
• Predicted Protein Size: 43 kDa
• Gene Name: mitogen-activated protein kinase-activated protein kinase 3
• Database Link:
  Entrez Gene 7867 Human
  UniProt ID Q16644
• Background: This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation. Alternate splicing results in multiple transcript variants that encode the same protein.
• Synonyms: 3PK; MAPKAP3; MAPKAPK-3; OTTHUMP00000210806