RASGRP1 Rabbit Polyclonal Antibody

CAT#: TA361294

RASGRP1 Antibody - middle region

Product Images

Host: Rabbit Target Name: RASGRP1 Sample Tissue: Human HepG2 Whole Cell lysates Antibody Dilution: 1ug/ml

Specifications

Product Data

• Applications: WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human RASGRP1
• Specificity: Expected reactivity: Human
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
  Note that this product is shipped as lyophilized powder to China customers.
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: 87 kDa
• Gene Name: RAS guanyl releasing protein 1
• Database Link:
  NP_001122074.1
  Entrez Gene 10125 Human
  UniProt ID O95267
• Background: This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE).
• Synonyms: CALDAG-GEFI; CalDAG-GEFII; hRasGRP1; MGC129998; MGC129999; RASGRP; V

Reference Data

• Protein Pathways: MAPK signaling pathway, T cell receptor signaling pathway