Calnexin (CANX) Rabbit Polyclonal Antibody

CAT#: TA326441

Rabbit Polyclonal Anti-Calnexin -CT Antibody

Product Images

Western blot analysis of purified calnexin-CT in a rat tissue mix using a 1:1000 dilution of the antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:2000
• Reactivities: Human, Monkey, Mouse, Rat, Bovine, Dog, Hamster, Rabbit, Pig, Quail, Sheep, Xenopus (weak), Guinea Pig, Drosophila (weak), Chicken (weak)
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Dog Calnexin C-terminal synthetic peptide conjugated to KLH. Identical to human, mouse and rat calnexin sequences over these residues.
• Formulation: PBS pH7.2, 50% glycerol, 0.09% sodium azide
• Concentration: lot specific
• Purification: Protein A Purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: calnexin
• Database Link:
  NP_001737
  Entrez Gene 12330 MouseEntrez Gene 29144 RatEntrez Gene 403908 DogEntrez Gene 704794 MonkeyEntrez Gene 821 Human
  UniProt ID P27824
• Background: Calnexin, an abundant ~90kDa integral protein of the endoplasmic reticulum, is also referred to as IP90, p88 and p90 . It consists of a large 50kDa N-terminal calcium-binding luminal domain, a single transmembrane helix and a short acidic cytoplasmic tail . Unlike its ER counterparts which have a KDEL sequence on their C-terminus to ensure ER retention , calnexin has positively charged cytosolic residues that do the same thing . Most ER proteins act as molecular chaperones and participate in the proper folding of polypeptides and their assembly into mulitsubunit proteins. Calnexin together with calreticulin, plays a key role in glycoprotein folding and its control within the ER, by interacting with folding intermediates via their monoglycosylated glycans . Calnexin has also been shown to associate with the major histocompatability complex class I heavy chains, partial complexes of the T cell receptor and B cell membrane immunoglobulin .
• Synonyms: CNX; IP90; P90
• Note: Detects ~90kDa.

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Antigen processing and presentation