Factor XI (F11) Rabbit Polyclonal Antibody

CAT#: TA308541

Rabbit Polyclonal antibody to Factor XI (coagulation factor XI)

Product Images

Sample (30 ug of whole cell lysate). A:293T. 7.5% SDS PAGE. TA308541 diluted at 1:1000

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  Immunohistochemical analysis of paraffin-embedded Breast ca, using Factor XI (TA308541) antibody at 1:250 dilution.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: IHC:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human (Predicted: Dog, Rabbit)
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 1 and 312 of Factor XI (Uniprot ID#P03951)
• Formulation: 1XPBS, 1% BSA, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 70 kDa
• Gene Name: coagulation factor XI
• Database Link:
  NP_000119
  Entrez Gene 475623 DogEntrez Gene 2160 Human
  UniProt ID P03951
• Background: This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq]
• Synonyms: FXI
• Note: Seq homology of immunogen across species: Dog (83%), Rabbit (82%)

Reference Data

• Protein Families: Druggable Genome, Protease, Secreted Protein
• Protein Pathways: Complement and coagulation cascades