MC4 Receptor (MC4R) Rabbit Polyclonal Antibody

CAT#: TA306791

Rabbit Polyclonal MC4R Antibody

Product Images

Western blot analysis of MC4R in rat brain tissue lysate with MC4R antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.

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  Immunohistochemistry of MC4R in human brain tissue with MC4R antibody at 2.5 ug/ml.

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  Immunofluorescence of MC4R in Human Brain cells with MC4R antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: MC4R antibody was raised against a 19 amino acid peptide near the amino terminus of human MC4R.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: melanocortin 4 receptor
• Database Link:
  NP_005903
  Entrez Gene 17202 MouseEntrez Gene 25635 RatEntrez Gene 4160 Human
  UniProt ID P32245
• Background: The melanocortin-4 receptor (MC4R) is a member of the superfamily of seven transmembrane G-protein coupled receptors that are involved in multiple signal transduction pathways including the cAMP and MAPK signaling pathways. It is thought that the melanocortin system modulates energy expenditure and insulin sensitivity; activation of the MC4R results in the inhibition of c-Jun N-terminal kinase (JNK) activity and promotes insulin signaling. MC4R-null mice display maturity onset obesity characterized by hyperphagia, increased adiposity, hyperinsulinaemia and hyperleptinaemia, suggesting that like other obesity-linked genes such as FTO, PTER, and NPC1, MC4R is a potential candidate target for the treatment of obesity.
• Synonyms: MGC126851; MGC138197

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Neuroactive ligand-receptor interaction