Caspase 4 (CASP4) Goat Polyclonal Antibody

CAT#: TA302442

Goat Polyclonal Antibody against CASP4

Product Images

TA302442 (0.3ug/ml) staining of Human Heart lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1:16,000. WB: 0.3-2µg/ml.
• Reactivities: Human (Expected from sequence similarity: Mouse, Feline, Dog, Cow)
• Host: Goat
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Peptide with sequence CKERAEEIYPIKERN, from the internal region of the protein sequence according to NP_001216; NP_150649; NP_150650.
• Formulation: Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
• Concentration: lot specific
• Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 46888 Da
• Gene Name: caspase 4
• Database Link:
  NP_001216
  Entrez Gene 12363 MouseEntrez Gene 403724 DogEntrez Gene 837 Human
  UniProt ID P49662
• Background: This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq]
• Synonyms: ICE(rel)II; ICEREL-II; ICH-2; Mih1; TX

Reference Data

• Protein Families: Druggable Genome, Protease