VEGF Receptor 1 (FLT1) Rabbit Polyclonal Antibody

CAT#: DP077-05

VEGF Receptor 1 (FLT1) rabbit polyclonal antibody, Purified

Product Images

Formalin fixed paraffin embedded human angiosarcoma stained with Flt-1 antibody DP077 / DP077-05

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Formalin-Fixed Paraffin Embedded Tissues: Use a dilution of 1/50-1/100 in an ABC method (incubation period of 30 minutes at room temperature).
  Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 10 mM citrate buffer, pH 6.0, prior to immunostaining.
  Recommended Positive Control: Angiosarcoma.
  Also useful for Western blotting.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: A synthetic peptide derived from the C-terminus of the Flt-1 precursor of human origin
• Specificity: This antibody reacts with a 180 kD protein, known as Flt-1/Vascular Endothelial Growth Factor Receptor 1.
  Cellular localization: cytoplasmic.
• Formulation: State: Purified
  State: Liquid purified Ig fraction with Sodium Azide as preservative.
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C.
• Stability: Shelf life: One year from despatch.
• Gene Name: fms related tyrosine kinase 1
• Database Link:
  Entrez Gene 2321 Human
  UniProt ID P17948
• Background: VEGF Receptor 1 (also known as FLT) belongs to the src gene family and shows tyrosine protein kinase activity that is important for the control of cell proliferation and differentiation. The protein acts as a receptor for VEGF, VEGFB and PGF. An alternatively spliced form of the gene produces a soluble protein (sFlt1) which binds vascular endothelial growth factor (VEGF) with high affinity. sFlt1 has a higher affinity for VEGF indicating that it may function as an inhibitor in the VEGF response. VEGF Receptor 1 is specifically expressed in most vascular endothelial cells and peripheral blood monocytes.
  Flt-1 is a cell membrane receptor kinase. Flk-1 has a high affinity receptor for vascular endothelial growth factor and is putatively involved in the growth of endothelial cells and angiogenesis.
• Synonyms: VEGFR1, FLT1, FLT, FRT, VEGF Receptor 1