VEGF Receptor 1 (FLT1) Mouse Monoclonal Antibody [Clone ID: #EWC]
CAT#: DM3504
VEGF Receptor 1 (FLT1) mouse monoclonal antibody, clone #EWC (formerly FLTEWC), Purified
Other products for "FLT1"
Specifications
Product Data | |
Clone Name | #EWC |
Applications | ELISA, IF, WB |
Recommended Dilution | ELISA: 1-10 µg/ml IgG1. Western Blot: 2-5 µg/ml IgG1. Immunofluorescence: 2-10 µg/ml. |
Reactivities | Human, Mouse |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Recombinant Human soluble extracellular Flt-1 protein (D5) (Cat.-No DA3539X) |
Specificity | The monoclonal antibody will detect native and denaturated VEGFR-1/Flt-1 in ELISA experiments and on the surface of different Human cell types. The antibody will also detect Mouse Flt-1. This clone was formerly named FLTEWC. |
Formulation | PBS, pH 6.0 without preservatives or stabilizers State: Purified State: Lyophilized purified IgG fraction from cell culture supernatant |
Reconstitution Method | Restore with distilled sterile water to a concentration of 0.1-1.0 mg/ml. |
Purification | Protein G Chromatography |
Conjugation | Unconjugated |
Storage | Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Gene Name | fms related tyrosine kinase 1 |
Database Link | |
Background | VEGF Receptor 1 (also known as FLT) belongs to the src gene family and shows tyrosine protein kinase activity that is important for the control of cell proliferation and differentiation. The protein acts as a receptor for VEGF, VEGFB and PGF. An alternatively spliced form of the gene produces a soluble protein (sFlt1) which binds vascular endothelial growth factor (VEGF) with high affinity. sFlt1 has a higher affinity for VEGF indicating that it may function as an inhibitor in the VEGF response. VEGF Receptor 1 is specifically expressed in most vascular endothelial cells and peripheral blood monocytes. VEGF and its high-affinity binding receptors, the tyrosine kinases FLK1 and FLT1, are thought to be important for the development of embryonic vasculature. It has been shown that an alternately spliced form of FLT1 produces a soluble protein, termed sFLT1, which binds vascular endothelial growth factor with high affinity. Because sFLT1 has a higher affinity for VEGF than does FLK1, it may function as an inhibitor of VEGF response. |
Synonyms | VEGFR1, FLT1, FLT, FRT, VEGF Receptor 1 |
Reference Data |
Documents
Product Manuals |
FAQs |
SDS |
{0} Product Review(s)
0 Product Review(s)
Submit review
Be the first one to submit a review
Product Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.