Thrombin Receptor (F2R) (24-37) Goat Polyclonal Antibody

CAT#: AP23067PU-N

Thrombin Receptor (F2R) (24-37) goat polyclonal antibody, Aff - Purified

Product Images

Western blot: Staining (0.5 ug/ml) of HeLa lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

• 

  Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA: 1/3200.
  Immunohistochemistry on Paraffin Sections: 2.5 µg/ml.
  Western Blot: 0.5 - 2 µg/ml.
• Reactivities: Human
• Host: Goat
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from the Internal region (near N-terminus) of the human protein sequence according to NP_001983.2
• Specificity: This antibody detects Thrombin receptor / F2R at internal region (near N-terminus).
• Formulation: Tris saline buffer, pH 7.3 containing 0.5% BSA as stabilizer and 0.02% sodium azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: coagulation factor II thrombin receptor
• Database Link:
  Entrez Gene 2149 Human
  UniProt ID P25116
• Background: Thrombin Receptor is a Proteinase-Activated Receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. Thrombin induced RANTES expression through a PAR-1 mediated pathway influences inflammatory cell migration to the synovium in patients with rheumatoid arthritis.
• Synonyms: Proteinase-activated receptor 1, PAR-1, PAR1, CF2R

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Calcium signaling pathway, Complement and coagulation cascades, Endocytosis, Neuroactive ligand-receptor interaction, Regulation of actin cytoskeleton