SNAIL (SNAI1) pSer246 Rabbit Polyclonal Antibody

CAT#: AP20798PU-N

SNAIL (SNAI1) pSer246 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of p-SNAI 1 antibody (Cat.-No.: AP20798PU-N) in extracts from HT29 cells.

• 

  Immunohistochemistry (IHC) analyzes of p-SNAI 1 antibody (Cat.-No.: AP20798PU-N) in paraffin-embedded human lung carcinoma tissue.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.
  Immunohistochemistry on paraffin sections: 1/50 - 1/200.
  Immunofluorescence: 1/50 - 1/200.
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of p-SNAI 1 protein, only when phosphorylated at Ser246.
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography (> 95% (by SDS-PAGE)
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 29 kDa
• Gene Name: snail family transcriptional repressor 1
• Database Link:
  Entrez Gene 20613 MouseEntrez Gene 6615 Human
  UniProt ID O95863
• Background: The SNAIL family of developmental regulatory proteins is a group of widely conserved zinc-finger proteins that regulate transcription and include the mammalian proteins SLUG, SNAI 1, the human homolog of DrosophilaSNAIL,and Smuc. SNAI 1 and SLUG are expressed in placenta and adult heart, liver and skeletal muscle. SNAI 1, and the corresponding mouse homolog Sna,each contain three classic zinc fingers and one atypical zinc finger, while SLUG contains five zinc finger regions and a transcriptional repression domain at the amino terminus, which enables SLUG to act as a negative regulator of gene expression. SLUG is implicated in the generation and migration of neural crest cells in human embryos and also contributes to limb bud development.
• Synonyms: SNAH, Protein snail homolog 1

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Adherens junction