PXR (NR1I2) (Center) Rabbit Polyclonal Antibody

CAT#: AP18142PU-N

PXR (NR1I2) (Center) rabbit polyclonal antibody

Product Images

Western blot analysis of NR1I2 Antibody (Center) in HL-60 cell line lysates (35ug/lane). NR1I2 (arrow) was detected using the purified Pab.

Specifications

Product Data

• Applications: FC, IF, IHC, WB
• Recommended Dilution: ELISA: 1/1,000.
  Western blotting: 1/1000.
  Immunohistochemistry: 1/50 - 1/100.
  Flow Cytometry: 1/10 - 1/50
  Immunoflourescence: 1/10 - 1/50
  
  
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 100-127 aa selected from the Center region of human NR1I2
• Specificity: This antibody reacts to NR1I2.
• Formulation: PBS with 0.09% (W/V) sodium azide
  State: Liquid purified Ig
• Concentration: lot specific
• Purification: Affinity chromatography on Protein A
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: 49762 Da.
• Gene Name: nuclear receptor subfamily 1 group I member 2
• Database Link:
  Entrez Gene 8856 Human
  UniProt ID O75469
• Background: NR1I2 belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. This protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin.
• Synonyms: PXR

Reference Data

• Protein Families: Druggable Genome, Nuclear Hormone Receptor, Transcription Factors