CCN4 (Center) Rabbit Polyclonal Antibody
Other products for "CCN4"
Specifications
Product Data | |
Applications | IHC, WB |
Recommended Dilution | ELISA: 1/1,000. Immunohistochemistry: 1/50 - 1/100. Western Blot. |
Reactivities | Human |
Host | Rabbit |
Isotype | Ig |
Clonality | Polyclonal |
Immunogen | This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human WISP1. |
Specificity | This antibody reacts to WISP1. |
Formulation | PBS with 0.09% (W/V) sodium azide State: Purified State: Liquid purified Ig |
Concentration | lot specific |
Purification | Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS |
Conjugation | Unconjugated |
Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Gene Name | WNT1 inducible signaling pathway protein 1 |
Database Link | |
Background | Wisp1 is a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. Wisp1 may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. |
Synonyms | CCN4 |
Reference Data |
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