ADAM17 (N-term) Rabbit Polyclonal Antibody

CAT#: AP11507PU-N

ADAM17 (N-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of ADAM17 Antibody (N-term)in CEM cell line lysates (35 ug/lane). ADAM17 (arrow) was detected using the purified Pab (1:60 dilution).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1,000.
  Western blot: 1/50-1/100.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human ADAM17.
• Specificity: This antibody detects ADAM17 at N-term.
• Formulation: PBS with 0.09% (W/V) Sodium Azide as preservative.
  State: Aff - Purified
  State: Liquid purified Ig fraction.
• Concentration: lot specific
• Purification: Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. Then the antibody is purified by peptide affinity purification.
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: ADAM metallopeptidase domain 17
• Database Link:
  Entrez Gene 6868 Human
  UniProt ID P78536
• Background: ADAM17 is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. ADAM17 functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway.
• Synonyms: CSVP, TACE
• Note: Calculated Molecular weight: 93021 Da