IRF7 (C-term) Rabbit Polyclonal Antibody

CAT#: AP07762PU-N

IRF7 (C-term) rabbit polyclonal antibody, Purified

Product Images

Figure 1. Formalin-Fixed Paraffin-Embedded (FFPE) on Thymus.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot: 1 - 2 µg/ml.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic Peptide corresponding to 14 amino acids near the carboxy-terminus of human IRF7.
• Specificity: This antibody reacts with Interferon Regulatory Factor 7 (IRF7).
• Formulation: Phosphate Buffered Saline PBS containing 0.02% Sodium Azide as preservative.
  State: Purified
  State: Liquid purified IgG fraction.
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or
  (in aliquots) at -20°C for longer.
  Dilute only prior to immediate use.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: interferon regulatory factor 7
• Database Link:
  Entrez Gene 3665 Human
  UniProt ID Q92985
• Background: Interferons (IFNs) are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes.
  IRF7 play a major role in the innate immune pathway, interacting with the Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM and functioning as an intermediate TLR4 and TLR9 signaling (3,4). Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established.
• Synonyms: IRF-7