DLL4 Rabbit Polyclonal Antibody

CAT#: AP05661PU-N

DLL4 rabbit polyclonal antibody, Purified

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: Immunohistochemistry on paraffin sections: 5 - 15µg/ml.
  ELISA: 1:3000 - 1:15000.
  Western Blot: 1:300 - 1:1500; detects a band of approximately 74kDa in pancreatic cell lysates.
• Reactivities: Human, Monkey, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to the internal region of human DLL4.
• Specificity: This antibody detects human Delta-like ligand 4 (DLL4), also known as Delta-4.
• Formulation: Phosphate buffered saline pH7.2 containing 0.09% Sodium Azide (NaN3)
  State: Purified
  State: Liquid purified IgG
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: delta like canonical Notch ligand 4
• Database Link:
  Entrez Gene 54485 MouseEntrez Gene 311332 RatEntrez Gene 54567 Human
  UniProt ID Q9NR61
• Background: DLL4 is a homologue of the Drosophila delta protein, and functions as a transmembrane bound ligand to the Notch receptor Notch1.
  DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF), as a negative feedback regulator to regulate angiogenic sprouting and promote the formation of a differentiated vascular network.
  DLL4 has been found to be strongly expressed in tumour vessels of clear-cell renal tumours and bladder cancer, and inhibition of DLL4 results in increased vascular proliferation but defective maturation. This in turn leads to a decrease in tumour growth, with no apparent toxicity.
• Synonyms: Delta 4, Drosophila Delta homolog 4

Reference Data

• Protein Families: Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Stem cell relevant signaling - DSL/Notch pathway, Transmembrane
• Protein Pathways: Notch signaling pathway