ABCG2 Mouse Monoclonal Antibody [Clone ID: BXP-34]
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Product Data | |
Clone Name | BXP-34 |
Applications | IF, IHC, WB |
Recommended Dilution | Flow Cytometry: 1/20 (Permeabilisation required). Immunocytochemistry: Use 1/20-1/50 on Acetone Fixed Cytospin preparations. Immunohistochemistry on Frozen Sections: 1/20 on Acetone Fixed Frozen Sections can be followed by incubation with Rabbit anti-Mouse IgG (1/25) and and a Monoclonal mouse APAAP complex (1/50). This antibody BXP-34 is unreactive in Western blot and cannot be used on Formaldehyde-Fixed Paraffin-Embedded Human tissues and tumours. |
Reactivities | Human |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Immunization with the mitoxanthrone resistant, BCRP overexpressing cell line MCF7 MR. |
Specificity | This Monoclonal antibody BXP-34 reacts with an internal epitope of BCRP, a 70 kD transmembrane half-transporter which is involved in multidrug resistance. It did not cross-react with the Human MDR1, MRP1, MRP2, MRP5 gene products. |
Formulation | State: Liquid Stabilizer: 1% BSA Preservative: 0.09% Sodium Azide |
Concentration | lot specific |
Conjugation | Unconjugated |
Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. |
Stability | Shelf life: one year from despatch. |
Gene Name | ATP binding cassette subfamily G member 2 (Junior blood group) |
Database Link | |
Background | The breast cancer resistance protein (BCRP/ABCG2) is a member of the ATP-binding cassette family of drug transporters and confers resistance to various anticancer drugs. The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. |
Synonyms | Breast cancer resistance protein 1, ABCP, MXR |
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