DLL4 Mouse Monoclonal Antibody [Clone ID: MHD4-46]

CAT#: AM26790PU-N

DLL4 mouse monoclonal antibody, clone MHD4-46, Purified

Specifications

Product Data

• Clone Name: MHD4-46
• Applications: FC, FN
• Recommended Dilution: Flow cytometry.
  Functional application: blocking.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant soluble human DLL4
• Specificity: This antibody MHD4-46 recognizes the extracellular domain of DLL4 (Delta-like ligand 4), a type I transmembrane protein which plays an important role in vascular development.
• Formulation: Phosphate buffered saline (PBS)
  State: Purified
  State: Liquid Ig fraction
  Preservative: 15 mM sodium azide, approx. pH 7.4
• Concentration: lot specific
• Purification: Protein-A affinity chromatography
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C.
  DO NOT FREEZE!
  
• Stability: Shelf life: one year from despatch.
• Gene Name: delta like canonical Notch ligand 4
• Database Link:
  Entrez Gene 54567 Human
  UniProt ID Q9NR61
• Background: DLL4 (Delta-like 4) is one of five ligands of Notch receptors. It interacts with Notch1 and Notch4. DLL4 is up-regulated at sites of physiologic and pathologic angiogenesis, whereas its expression is low in most adult normal tissues. It is also highly expressed in human clear-cell renal carcinomas, bladder cancers, and breast cancers. Blocking the DLL4-Notch interaction seems to be a promissing therapeutic approach.
• Synonyms: Delta 4, Drosophila Delta homolog 4