hCG (CGA) Mouse Monoclonal Antibody [Clone ID: TSH-1]

CAT#: AM09311PU-N

hCG (CGA) mouse monoclonal antibody, clone TSH-1, Aff - Purified

Specifications

Product Data

• Clone Name: TSH-1
• Applications: ELISA
• Recommended Dilution: ELISA: This antibody can be used as Capturer in Sandwich ELISA with our Matched anti-TSH Antibody Mouse anti Human TSH monoclonal antibody, HRP-conjugated, Cat.-No AM09312HR-N.
  The suggested capturer coating quantity is 4 µg/ml.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant Human TSH
• Specificity: This antibody is reactive to Alpha chain of Human TSH.
• Formulation: 0.01M PBS, pH 7.2 without preservatives
  State: Aff - Purified
  State: Lyophilized purified IgG fraction
• Reconstitution Method: Restore with Double distillated water to adjust the final concentration to 1.0 mg/ml.
• Concentration: 1.0 mg/ml (after reconstitution)
• Purification: Affinity Chromatography on Protein G
• Conjugation: Unconjugated
• Storage: Upon receipt, store undiluted (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: One year from despatch.
• Gene Name: glycoprotein hormones, alpha polypeptide
• Database Link:
  Entrez Gene 1081 Human
  UniProt ID P01215
• Background: Thyroid stimulating hormone (TSH), also known as thyrotropin, is secreted from cells in the anterior pituitary called thyrotrophs, finds its receptors on epithelial cells in the thyroid gland, and stimulates that gland to synthesize and release thyroid hormones.
  TSH is a glycoprotein hormone composed of two subunits which are non covalently bound to one another. The alpha subunit of TSH is also present in two other pituitary glycoprotein hormones, follicle stimulating hormone and luteinizing hormone, and, in primates, in the placental hormone chorionic gonadotropin. Each of these hormones also has a unique beta subunit, which provides receptor specificity. In other words, TSH is composed of alpha subunit bound to the TSH beta subunit, and TSH associates only with its own receptor. Free alpha and beta subunits have essentially no biological activity.
  TSH has a alpha subunit that is identical to the one in other glycoprotein hormones such as LH, FSH and HCG.
• Synonyms: Follitropin alpha chain, Follicle-stimulating hormone alpha chain, FSH-alpha, Lutropin alpha chain, Luteinizing hormone alpha chain, LSH-alpha, LH alpha, Thyrotropin alpha chain, Thyroid-stimulating hormone alpha chain, TSH-alpha, Choriogonadotropin alpha chain, Chorionic gonadotrophin subunit alpha, hCG-alpha

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein
• Protein Pathways: Autoimmune thyroid disease, GnRH signaling pathway, Neuroactive ligand-receptor interaction