Estrogen Receptor beta (ESR2) (NM_001437) Human Recombinant Protein

CAT#: TP710031

Recombinant protein of human estrogen receptor 2 (ER beta) (ESR2), full length, with C-terminal DDK tag, expressed in sf9 cells.

Product Images

Specifications

Product Data

• Species: Human
• Expression Host: Sf9
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  A DNA sequence from TrueORF clone, RC218519, encoding human full-length ESR2
• Tag: C-DDK
• Predicted MW: 59 kDa
• Concentration: >0.1 µg/µL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 50 mM Tris-HCl, 100 mM glycine, pH 8.0, 10% glycerol
• Bioactivity: Binding assay (PMID: 28842010)
• Note: For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
• Storage: Store at -80°C.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_001428
• Locus ID: 2100
• UniProt ID: Q92731, Q7LCB3
• Cytogenetics: 14q23.2-q23.3
• Refseq Size: 2011
• Refseq ORF: 1590
• Synonyms: ER-BETA; Erb; ESR-BETA; ESRB; ESTRB; NR3A2; ODG8
• Summary: This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]
• Protein Families: Druggable Genome, Nuclear Hormone Receptor, Transcription Factors