Xanthine Oxidase (XDH) (NM_000379) Human Untagged Clone

CAT#: SC300061

XDH (untagged)-Human xanthine dehydrogenase (XDH)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: Xanthine Oxidase
• Synonyms: XAN1; XO; XOR
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_000379 edited
  AACCTGTGACAATGACAGCAGACAAATTGGTTTTCTTTGTGAATGGCAGAAAGGTGGTGG
  AGAAAAATGCAGATCCAGAGACAACCCTTTTGGCCTACCTGAGAAGAAAGTTGGGGCTGA
  GTGGAACCAAGCTCGGCTGTGGAGAGGGGGGCTGCGGGGCTTGCACAGTGATGCTCTCCA
  AGTATGATCGTCTGCAGAACAAGATCGTCCACTTTTCTGCCAATGCCTGCCTGGCCCCCA
  TCTGCTCCTTGCACCATGTTGCAGTGACAACTGTGGAAGGAATAGGAAGCACCAAGACGA
  GGCTGCATCCTGTGCAGGAGAGAATTGCCAAAAGCCACGGCTCCCAGTGCGGGTTCTGCA
  CCCCTGGCATCGTCATGAGTATGTACACACTGCTCCGGAATCAGCCCGAGCCCACCATGG
  AGGAGATTGAGAATGCCTTCCAAGGAAATCTGTGCCGCTGCACAGGCTACAGACCCATCC
  TCCAGGGCTTCCGGACCTTTGCCAGGGATGGTGGATGCTGTGGAGGAGATGGGAATAATC
  CAAATTGCTGCATGAACCAGAAGAAAGACCACTCAGTCAGCCTCTCGCCATCTTTATTCA
  AACCAGAGGAGTTCACGCCCCTGGATCCAACCCAGGAGCCCATTTTTCCCCCAGAGTTGC
  TGAGGCTGAAAGACACTCCTCGGAAGCAGCTGCGATTTGAAGGGGAGCGTGTGACGTGGA
  TACAGGCCTCAACCCTCAAGGAGCTGCTGGACCTCAAGGCTCAGCACCCTGACGCCAAGC
  TGGTCGTGGGGAACACGGAGATTGGCATTGAGATGAAGTTCAAGAATATGCTGTTTCCTA
  TGATTGTCTGCCCAGCCTGGATCCCTGAGCTGAATTCGGTAGAACATGGACCCGACGGTA
  TCTCCTTTGGAGCTGCTTGCCCCCTGAGCATTGTGGAAAAAACCCTGGTGGATGCTGTTG
  CTAAGCTTCCTGCCCAAAAGACAGAGGTGTTCAGAGGGGTCCTGGAGCAGCTGCGCTGGT
  TTGCTGGGAAGCAAGTCAAGTCTGTGGCGTCCGTTGGAGGGAACATCATCACTGCCAGCC
  CCATCTCCGACCTCAACCCCGTGTTCATGGCCAGTGGGGCCAAGCTGACACTTGTGTCCA
  GAGGCACCAGGAGAACTGTCCAGATGGACCACACCTTCTTCCCTGGCTACAGAAAGACCC
  TGCTGAGCCCGGAGGAGATACTGCTCTCCATAGAGATCCCCTACAGCAGGGAGGGGGAGT
  ATTTCTCAGCATTCAAGCAGGCCTCCCGGAGAGAAGATGACATTGCCAAGGTAACCAGTG
  GCATGAGAGTTTTATTCAAGCCAGGAACCACAGAGGTACAGGAGCTGGCCCTTTGCTATG
  GTGGAATGGCCAACAGAACCATCTCAGCCCTCAAGACCACTCAGAGGCAGCTTTCCAAGC
  TCTGGAAGGAGGAGCTGCTGCAGGACGTGTGTGCAGGACTGGCAGAGGAGCTGCATCTGC
  CTCCCGATGCCCCTGGTGGCATGGTGGACTTCCGGTGCACCCTCACCCTCAGCTTCTTCT
  TCAAGTTCTACCTGACAGTCCTTCAGAAGCTGGGCCAAGAGAACCTGGAAGACAAGTGTG
  GTAAACTGGACCCCACTTTCGCCAGTGCAACTTTACTGTTTCAGAAAGACCCCCCAGCCG
  ATGTCCAGCTCTTCCAAGAGGTGCCCAAGGGTCAGTCTGAGGAGGACATGGTGGGCCGGC
  CCCTGCCCCACCTGGCAGCGGACATGCAGGCCTCTGGTGAGGCCGTGTACTGTGACGACA
  TTCCTCGCTACGAGAATGAGCTGTCTCTCCGGCTGGTCACCAGCACCCGGGCCCACGCCA
  AGATCAAGTCCATAGATACATCAGAAGCTAAGAAGGTTCCAGGGTTTGTTTGTTTCATTT
  CCGCTGATGATGTTCCTGGGAGTAACATAACTGGAATTTGTAATGATGAGACAGTCTTTG
  CGAAGGATAAGGTTACTTGTGTTGGGCATATCATTGGTGCTGTGGTTGCTGACACCCCGG
  AACACACACAGAGAGCTGCCCAAGGGGTGAAAATCACCTATGAAGAACTACCAGCCATTA
  TCACAATTGAGGATGCTATAAAGAACAACTCCTTTTATGGACCTGAGCTGAAGATCGAGA
  AAGGGGACCTAAAGAAGGGGTTTTCCGAAGCAGATAATGTTGTGTCAGGGGAGATATACA
  TCGGTGGCCAAGAGCACTTCTACCTGGAGACTCACTGCACCATTGCTGTTCCAAAAGGCG
  AGGCAGGGGAGATGGAGCTCTTTGTGTCTACACAGAACACCATGAAGACCCAGAGCTTTG
  TTGCAAAAATGTTGGGGGTTCCAGCAAACCGGATTGTGGTTCGAGTGAAGAGAATGGGAG
  GAGGCTTTGGAGGCAAGGAGACCCGGAGCACTGTGGTGTCCACGGCAGTGGCCCTGGCTG
  CATATAAGACCGGCCGCCCTGTGCGATGCATGCTGGACCGTGATGAGGACATGCTGATAA
  CTGGTGGCAGACATCCCTTCCTGGCCAGATACAAGGTTGGCTTCATGAAGACTGGGACAG
  TTGTGGCTCTTGAGGTGGACCACTTCAGCAATGTGGGGAACACCCAGGATCTCTCTCAGA
  GTATTATGGAACGAGCTTTATTCCACATGGACAACTGCTATAAAATCCCCAACATCCGGG
  GCACTGGGCGGCTGTGCAAAACCAACCTTCCCTCCAACACGGCCTTCCGGGGCTTTGGGG
  GGCCCCAGGGGATGCTCATTGCCGAGTGCTGGATGAGTGAAGTTGCAGTGACCTGTGGGA
  TGCCTGCAGAGGAGGTGCGGAGAAAAAACCTGTACAAAGAAGGGGACCTGACACACTTCA
  ACCAGAAGCTTGAGGGTTTCACCTTGCCCAGATGCTGGGAAGAATGCCTAGCAAGCTCTC
  AGTATCATGCTCGGAAGAGTGAGGTTGACAAGTTCAACAAGGAGAATTGTTGGAAAAAGA
  GAGGATTGTGCATAATTCCCACCAAGTTTGGAATAAGCTTCACAGTTCCTTTTCTGAATC
  AGGCAGGAGCCCTACTTCATGTGTACACAGATGGCTCTGTGCTGCTGACCCACGGGGGGA
  CTGAGATGGGCCAAGGCCTTCATACCAAAATGGTCCAGGTGGCCAGTAGAGCTCTGAAAA
  TCCCCACCTCTAAGATTTATATCAGCGAGACAAGCACTAACACTGTGCCCAACACCTCTC
  CCACGGCTGCCTCTGTCAGCGCTGACCTCAATGGACAGGCCGTCTATGCGGCTTGTCAGA
  CCATCTTGAAAAGGCTGGAACCCTACAAGAAGAAGAATCCCAGTGGCTCCTGGGAAGACT
  GGGTCACAGCTGCCTACATGGACACAGTGAGCTTGTCTGCCACTGGGTTTTATAGAACAC
  CCAATCTGGGCTACAGCTTTGAGACTAACTCAGGGAACCCCTTCCACTACTTCAGCTATG
  GGGTGGCTTGCTCTGAAGTAGAAATCGACTGCCTAACAGGAGATCATAAGAACCTCCGCA
  CAGATATTGTCATGGATGTTGGCTCCAGTCTAAACCCTGCTATTGATATTGGACAGGTGG
  AAGGGGCATTTGTCCAGGGCCTTGGCCTCTTCACCCTAGAGGAGCTACACTATTCCCCCG
  AGGGGAGCCTGCACACCCGTGGCCCTAGCACCTACAAGATCCCGGCATTTGGCAGCATCC
  CCATTGAGTTCAGGGTGTCCCTGCTCCGCGACTGCCCCAACAAGAAGGCCATCTATGCAT
  CGAAGGCTGTTGGAGAGCCGCCCCTCTTCCTGGCTGCTTCTATCTTCTTTGCCATCAAAG
  ATGCCATCCGTGCAGCTCGAGCTCAGCACACAGGTAATAACGTGAAGGAACTCTTCCGGC
  TAGACAGCCCTGCCACCCCGGAGAAGATCCGCAATGCCTGCGTGGACAAGTTCACCACCC
  TGTGTGTCACTGGTGTCCCAGAAAACTGCAAACCCTGGTCTGTGAGGGTCTAAAGAGAGA
  GTCCTCAGCAGAGTCTTCTTGTGCTGCCTTTGGGCTTCCATGGAGCAGGAGGAACATACC
  ACAGAACATGGATCTATTAAAGTCACAGAATGACAGACCTGTGATTTGTCAAGATGGGAT
  TTGGAAGACAAGTGAATGCAATGGAAGATTTTGATCAAAAATGTAATTTGTAAACACAAT
  GATAAGCAAATTCAAAACTGTTATGCCTAAATGGTGAATATGCAATTAGGATCATTTTCT
  GTCTGTTTTAATCATGTATCTGGAATAGGGTCGGGAAGGGTTTGTGCTATTCCCCACTTA
  CTGGACAGCCTGTATAACCTCAAGTTCTGATGGTGTCTGTCCTTTGAAGAGGATTCCCAC
  AAACCTCTAGAAGCTTAAACCGAAGTTACTTTAAATCGTGTGCCTTCCTGTGAAAGCCTG
  GCCTTCAAACCAATGAACAGCAAAGCATAACCTTGAATCTATACTCAAATTTTGCAATGA
  GGCAGTGGGGTAAGGTTAAATCCTCTAACCATCTTTGAATCATTGGAAAGAATAAAGAAT
  GAAACAAATTCAAGGTTAATTGGATCTGATTTTGTGAAGCTGCATAAAGCAAGATTACTC
  TATAATACAAAAATCCAACCAACTCAATTATTGAGCACGTACAATGTTCTAGATTTCTTT
  CCCTTCCTCTTTGAAGAGAATATTTGTATTCCAAATACTCTTTGAGTATTTACAAAAAAG
  ATTATGTTTAATCTTTACATTTGAAGCCAAAGTAATTTCCACCTAGAAATGATGCTATCA
  GTCCTGGCATGGTGGCTCACCCCTATAATCCCAGCACTTTGGGAGGCTAAGGCAGGAGAA
  TTGCTTGAGCCCAGCAGTTTGAGACCAGCCTGGGCAACATAGAGAGCTCCTGTCTTTAAA
  AAAAATTTTTTTAATTAGTTGGTCTTGATAGTGCATGCCTGTAGTCCCAACTACTTGAAA
  GGCTGAGGTGGAGAGATCATTTGAGCTCAGGAGGTTGAGGCTGCAGTGAGCTATGATTGC
  GCCACTGCACTCCTGCCTGAGCGACTGAGCAAGATCTTGTCTCTGAAGAAAAAAAAAAAA
  AAAAAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_000379 unedited
  NNCCACGTTCACCATTTGTCATACGACTCATATAGGCGGCCGCGNATTCAGATCTGGTAC
  CGAGCTCGGNATCCCTAGTAACGGCCGCCAGTGTGCTGGAATTCGCCCTTAACCTGTGAC
  AATGACAGCAGACAAATTGGTTTTCTTTGTGAATGGCAGAAAGGTGGTGGAGAAAAATGC
  AGATCCAGAGACAACCCTTTTGGCCTACCTGAGAAGAAAGTTGGGGCTGAGTGGAACCAA
  GCTCGGCTGTGGAGAGGGGGGCTGCGGGGCTTGCACAGTGATGCTCTCCAAGTATGATCG
  TCTGCAGAACAAGATCGTCCACTTTTCTGCCAATGCCTGCCTGGCCCCCATCTGCTCCTT
  GCACCATGTTGCAGTGACAACTGTGGAAGGAATAGGAAGCACCAAGACGAGGCTGCATCC
  TGTGCAGGAGAGAATTGCCAAAAGCCACGGCTCCCAGTGCGGGTTCTGCACCCCTGGCAT
  CGTCATGAGTATGTACACACTGCTCCGGAATCAGGCCCGAGCCCACCATGGAGGAGATTG
  AGAATGCCTTCCAAGGAAATCTGTGCCGCTGCACAGGCTACAGACCCATCCTCCAGGGCT
  TCCGGACCTTTGGCCCAAGGGGGATGGTGGATGCTGTGGAGGAGATGGGAAATATCCAAA
  TTGCTGCCTGAACCAGAAGAAAGACCACTCAGTCAGCCTTNTTTTCGGCCCCAATCTTTT
  TTTTTCAAACCAAGAGAGATTTCACCCCCCTGGATCCCAAACCAGGAACCCATTTTTTCC
  CCCCAAATTGCTTGAAGCCTGAAAGAAACCTCCTCGGGAGCCACCTGCCAATTTAAAGGG
  AAACCTTGGAACTTGTATACCAGGCTTTAACCCTTAAGGGAACTGGTGGAACCTAC
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_000379 unedited
  TTGGGGGTTCTTGGTGAGGCAATTCCCGGACCGGCAAAGCACTGGGGCAGGGTCACAGGT
  ATGCCACCCGGGTTCTGTTCAGGAAACAGCTATGACCGCGGCCGCAATCATATAGTCGAG
  TTTTTTTTTTTTTTTTTTTTTCTTCAAAGACAAGATCTTGCTCAGTCGCTCAGGCAGGAG
  TGCAGTGGCCCATTCATAGCTCACTGACACCTCAAGCTCCTGAGCTCAAATGATCTCTCC
  GCCTAACCCTTTCAAGTAGTTGGTACTACCTGCATGCGCTATGAAGACCATTTAATTAAA
  AAAATTTTTTTTATAGACGGGATCTGTGTATGTTGCCCAGGCTGGTCTTAAACTGCTGGG
  CTCAAGCAATTCTCCTGCCTTATCCTCCCAAAGTGCCTGGTTTATTGGGGTGAACCACCC
  TGCCTGGACTGTTAACGTCATTTCTATGGGGAAATTACTTTGGTTTCGACTGTGAAGATT
  AAACACTGTCTCTTTTGGAAATGCTCGGAGACTATTTGAAATACATATTTTCTCCTCTGA
  ACGGAAGGGAAAGATTGCTCCCACTGTGCACGTGCTCAGTAATTGAGTCGGATGGATTTC
  TGGATTAATGATNAGATAATCTTGCTTTATGACGCTTCACACTATACTATGCCTTCTACC
  TAGAATTGGATCTGCTCTATATCCTTTCCGATAGGAATTCCCAATGGTCATGGGTTGAGA
  AGAATATATCCATTACCCCGCTGCCCTCATTGGGTTAATTCGAGTATGCTTTCAAGGTTA
  TCGCTTCGCTAGTTATATGCCTTTGAAAGCCCATGCTTCTCCCGGGATGGGCCCACGGGT
  TTCCAGTCTCTTGCCGTTCAAATCTTTTTAAAAGGTCTGTTTGGAATCG
  
• Restriction Sites: Please inquire
• ACCN: NM_000379
• Insert Size: 5100 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference.
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_000379.2, NP_000370.1
• RefSeq Size: 4428 bp
• RefSeq ORF: 4002 bp
• Locus ID: 7498
• UniProt ID: P47989
• Cytogenetics: 2p23.1
• Protein Families: Druggable Genome
• Protein Pathways: Caffeine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism
• Gene Summary: Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism. [provided by RefSeq, Jan 2014]