ACOX1 (NM_007292) Human Untagged Clone

CAT#: SC108887

ACOX1 (untagged)-Human acyl-CoA oxidase 1, palmitoyl (ACOX1), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ACOX1
• Synonyms: ACOX; MITCH; PALMCOX; SCOX
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_007292, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGAACCCGGACCTGCGCAGGGAGCGGGATTCCGCCAGCTTCAACCCGGAGCTGCTTACACACATCCTGG
  ACGGCAGCCCCGAGAAAACCCGGCGCCGCCGAGAGATCGAGAACATGATCCTGAACGACCCAGACTTCCA
  GCATGAGGACTTGAACTTCCTCACTCGCAGCCAGCGTTATGAGGTGGCTGTCAGGAAAAGTGCCATCATG
  GTGAAGAAGATGAGGGAGTTTGGCATCGCTGACCCTGATGAAATTATGTGGTTTAAAAAACTACATTTGG
  TCAATTTTGTGGAACCTGTGGGCCTCAATTACTCCATGTTTATTCCTACCTTGCTGAATCAGGGCACCAC
  TGCTCAGAAAGAGAAATGGCTGCTTTCATCCAAAGGACTCCAGATAATTGGCACCTACGCCCAGACGGAA
  ATGGGCCACGGAACTCACCTTCGAGGCTTGGAAACCACAGCCACGTATGACCCTGAAACCCAGGAGTTCA
  TTCTCAACAGTCCTACTGTGACCTCCATTAAATGGTGGCCTGGTGGGCTTGGAAAGACTTCAAATCATGC
  AATAGTTCTTGCCCAGCTCATCACTAAGGGGAAATGCTATGGATTACATGCCTTTATCGTACCTATTCGT
  GAAATCGGGACCCATAAGCCTTTGCCAGGAATTACCGTTGGTGACATCGGCCCCAAATTTGGTTATGATG
  AGATAGACAATGGCTACCTCAAAATGGACAACCATCGTATTCCCAGAGAAAACATGCTGATGAAGTATGC
  CCAGGTGAAGCCTGATGGCACATACGTGAAACCGCTGAGTAACAAGCTGACTTACGGGACCATGGTGTTT
  GTCAGGTCCTTCCTTGTGGGAGAAGCTGCTCGGGCTCTGTCTAAGGCGTGCACCATTGCCATCCGATACA
  GCGCTGTGAGGCACCAGTCTGAAATCAAGCCAGGTGAACCAGAACCACAGATTTTGGATTTTCAAACCCA
  GCAGTATAAACTCTTTCCACTCCTGGCCACTGCCTATGCCTTCCAGTTTGTGGGCGCATACATGAAGGAG
  ACCTATCACCGGATTAACGAAGGCATTGGTCAAGGGGACCTGAGTGAACTGCCTGAGCTTCATGCCCTCA
  CCGCTGGACTGAAGGCTTTCACCTCCTGGACTGCAAACACTGGCATTGAAGCATGTCGGATGGCTTGTGG
  TGGGCATGGCTATTCTCATTGCAGTGGTCTTCCAAATATTTATGTCAATTTCACCCCAAGCTGTACCTTT
  GAGGGAGAAAACACTGTCATGATGCTCCAGACGGCTAGGTTCCTGATGAAAAGTTATGATCAGGTGCACT
  CAGGAAAGTTGGTGTGTGGCATGGTGTCCTATTTGAACGACCTGCCCAGTCAGCGCATCCAGCCACAGCA
  GGTAGCAGTCTGGCCAACCATGGTGGATATCAACAGCCCCGAAAGCCTAACCGAAGCATATAAACTCCGT
  GCAGCCAGATTAGTAGAAATTGCTGCAAAAAACCTTCAAAAAGAAGTGATTCACAGAAAAAGCAAGGAGG
  TAGCTTGGAACCTAACTTCTGTTGACCTTGTTCGAGCAAGTGAGGCACATTGCCACTATGTGGTAGTTAA
  GCTCTTTTCAGAAAAACTCCTCAAAATTCAAGATAAAGCCATTCAAGCTGTCTTAAGGAGTTTATGTCTG
  CTGTATTCTCTGTATGGAATCAGTCAGAACGCGGGGGATTTCCTTCAGGGGAGCATCATGACAGAGCCTC
  AGATTACACAAGTAAACCAGCGTGTAAAGGAGTTACTCACTCTGATTCGCTCAGATGCTGTTGCTTTGGT
  TGATGCATTTGATTTTCAGGATGTGACACTTGGCTCTGTGCTTGGCCGCTATGATGGGAATGTGTATGAA
  AACTTGTTTGAGTGGGCTAAGAACTCCCCACTGAACAAAGCAGAGGTCCACGAATCTTACAAGCACCTGA
  AGTCACTGCAGTCCAAGCTCTGA
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_007292 unedited
  GAATTCGGCACGAGGACGCCCAGCAGGGCAATTTCTTGACCTTCGGAGCCCCTTTCCCGA
  GGATCCGCTCGGGAGCCTCCCCTGGCCAGGAGCAGGGGATTAGTCTGCCCCGCGACCGGC
  CCCAGCCACGACGCGGACATCGCCCCCTCTGTCTGGGCCGCTGTCACTCACGCGTCAAAG
  GGCCACGGAGAAAGAAGGGGCGGGCCGGGGCGGGCCGGGCGAGCGGAGGCGGGGACTTGC
  GCCGTCCTGAGGCTGCCTCCTAGGGTCCGGCCGGCGCTGGAGCTGCGGATTTAGATTGTC
  ACTGCCACCTCGGTCGGTGCTTACTTCGCTGCCAGCTGGTCGTCGCCATGAACCCGGACC
  TGCGCAGGGAGCGGGATTCCGCCAGCTTCAACCCGGAGCTGCTTACACACATCCTGGACG
  GCAGCCCCGAGAAAACCCGGCGCCGCCGAGAGATCGAGAACATGATCCTGAACGACCCAG
  ACTTCCAGCATGAGGACTTGAACTTCCTCACTCGCAGCCAGCGTTATGAGGTGGCTGTCA
  GGAAAAGTGCCATCATGGTGAAGAAGATGAGGGAGTTTGGCATCGCTGACCCTGATGAAA
  TTATGTGGTTTAAAAATTTTGTGCACCGAGGGCGGNCTGAGCCTCTGGATCTTCACTTGG
  GCATNGTCCTGCCCACCTTGCTTCACCANGCAACTGCNGAGCAGCAGGAGCGCTTCTTCA
  TGCCCGCCTGGAACTTGGNAGATCATTGGCACTTATGCC
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_007292 unedited
  TGCTTTGGACCGGCGGCCGCAATCTAGGGTCGAGTTTTTTTTTTTTTTTTTTTTTTTTTT
  TTTTTTTTTTTGACTTTAAAAAAAAATAATTAAGATGTATTTAACCTTTAAGTATAGAAT
  GATTGGATAAATTAGATTTCAACTGAAAGGACAATTAGCGATTCAGAGAAAGCTCCTAAA
  AATAGACTGAAAACAAAGCCCTACATAGAGTAAGAAATAGAACCTATGGAACTTCCATTT
  TTCTAACTATAGTTTTTTGGTTTTGGTTTTTCCCAGTTGTTAAAAAAAAAACAACTCACA
  GTTTCAATATTTTCTGAACCAAAAATCAGAACACATGGTTTGGGTCAAAGGGTTTTTCTG
  GGCTACGTCTGGGAGGGCTGACCTAAGGGACATTTTTTTTTAATGCCAAATACAGTAATC
  TCCAAGCTTTTAATGGCTTATGCCAAGATGACAGAATATGTGAAATCTGATTGTCCCAAA
  GTTACACTCTGCACTCCAAAGCTACAACAGTGCCACAGCTGAGAGGGTTCCCTATACTTC
  CTACTACTGGGACAATTTAGCGATCCTTCAAATGGAAAATTCCTAATTACACGAGACAAT
  GGTCCTACAGTAGGCCCGTGCGGAATAAGTTCCCTCGTTGGAAAAATGCTAGCATGAATA
  GTTTGATAAATGCCATCCATCAGCAAAGGAGAGCAAGCAGGCAGAGACTGTGCCAAGCAG
  AAACTCATTCGCATCAGGTTTCCAATAAGTTTCCTTTCCCCAGCCCCTTTTTTTAATCCT
  GCTTTAAGCCCAGCCCCAGGGTAAGTCTGTGAAACACTGAGCAGAAAGCTTGGAAGGTTC
  TAACACATTTAAAATACCCTTGCTAAAACACTTAATAGCCCGGGATAGCAATTAAATGGG
  AAATATCACCCCTCCGGGGTTAAATTCTGCTATATCAAAGGCATACCTACTGGAACAN
  
• Restriction Sites: NotI-NotI
• ACCN: NM_007292
• Insert Size: 3420 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_007292.3, NP_009223.2
• RefSeq Size: 3445 bp
• RefSeq ORF: 1983 bp
• Locus ID: 51
• UniProt ID: Q15067
• Cytogenetics: 17q25.1
• Protein Families: Druggable Genome
• Protein Pathways: alpha-Linolenic acid metabolism, Biosynthesis of unsaturated fatty acids, Fatty acid metabolism, Metabolic pathways, PPAR signaling pathway
• Gene Summary: The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (b, alternately known as ACOX1a per PMID: 17603022), is the same length as isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.