STING (TMEM173) (AK095896) Human Untagged Clone

CAT#: SC102596

(untagged)-Human cDNA FLJ38577 fis, clone HCHON2007650

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: STING
• Synonyms: ERIS; hMITA; hSTING; MITA; MPYS; NET23; SAVI; STING
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for AK095896, the custom clone sequence may differ by one or more nucleotides
  
  
  AAACCAGAAGAAAAATATGAGACGGGGAATCATCGTGTGATGTGTGTGCTGCCTTTGGCTGAGTGTGTGG
  AGTCCTGCTCAGGTGTTAGGTACAGTGTGTTTGATCGTGGTGGCTTGAGGGGAACCCGCTGTTCAGAGCT
  GTGACTGCGGCTGCACTCAGAGAAGCTGCCCTTGGCTGCTCGTAGCGCCGGGCCTTCTCTCCTCGTCATC
  ATCCAGAGCAGCCAGTGTCCGGGAGGCAGAAGATGCCCCACTCCAGCCTGCATCCATCCATCCCGTGTCC
  CAGGGGTCACGGGGCCCAGAAGGCAGCCTTGGTTCTGCTGAGTGCCTGCCTGGTGACCCTTTGGGGGCTA
  GGAGAGCCACCAGAGCACACTCTCCGGTACCTGGTCCTCCACCTAGCCTCCCTGCAGCTGGGACTGCTGT
  TAAACGGGGTCTGCAGCCTGGCTGAGGAGCTGCGCCACATCCACTCCAGGTGACTCACTGCAGTACCCAG
  GGACGGGGTATCCAACGTGTGTCACTCCCTTGATGCCTAGCCCTGCCCCTCCTTGAACCTCTCTGGCTGA
  GCTGGGCTGGGGGCTGGGGTCTGGGGTCTGGCTGTCACTCACAGGTACCGGGGCAGCTACTGGAGGACTG
  TGCGGGCCTGCCTGGGCTGCCCCCTCCGCCGTGGGGCCCTGTTGCTGCTGTCCATCTATTTCTACTACTC
  CCTCCCAAATGCGGTCGGCCCGCCCTTCACTTGGATGCTTGCCCTCCTGGGCCTCTCGCAGGCACTGAAC
  ATCCTCCTGGGCCTCAAGGTATGACACAGGGGGAGGTAGAAGCTCTGGCCAAGTGGTGGCTGTGGCTGGT
  GTGACCTGCCCTGAGCTGAGTACTGGGAGTGGGACTGGTTTAAAGGCTGGAGTCCATGGAGTAGAACCTA
  TAATGTCCTGGAACAGTGGGTTTGGCAATGGCAAAAGAGGGATCAAGTCAGGAGCAGGTTGGGAAGCCTT
  GGAGGAGGAGGAGGAGTTCTCTGGGTGTCCTTGATGGAGGCCCCCCAGCCACATCCTGCTGTCCACAGGG
  CCTGGCCCCAGCTGAGATCTCTGCAGTGTGTGAAAAAGGGAATTTCAACGTGGCCCATGGGCTGGCATGG
  TCATATTACATCGGATATCTGCGGCTGATCCTGCCAGCCTGGAGTACAGTGGTGACAAGATCTCAGCTCA
  CTGCAACCTCTGCCTCCCAGGTTCAAGTGATTCTCCTGCCTGAGCCTCTTGAATAGCTAGGATTACAGGC
  ACGTGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAATGTTTCACCATGTTGCCCAGGCTA
  GTCTCAAACTCCTGACCTCAAATGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGATTACAGGCGTGAGC
  CACTGTGCCTGCCCTAAGCCTGTGTGTTTTATTCTTCTGACTTGCAGGCTAAAGCGGCAGCTCTTCCATA
  TCTCATTGCTATCTCCTAGGGCTTCCGCTAGGAGACTGATCTGGGGCTAGAGGCCTCCCTCTGTGCACAC
  GAGAATGCTGGAAATGTCACCTCTCAGGGCTCTGCCTGCCTCTCAGCCCTGAAAGCCATGGTGGAAAGGG
  GTGGCGCTGACATAGACATCTGAGGAAAGAAGTGAGGGAGGGTAAAGGGTGGTGCAGTAAGAGGAGGGGT
  GGGGAGGGCTTTTGGAGGCGCTGCCCCTCCTGGCCTCCTGTACAATGAGAGTGCACTGGACTCTCCATTC
  TCTGGCACCCACACACTGCGGGGGCCAATGACCTGGGTCTCACTCCTGAATCAGGTGGGAGATAGGGTTA
  GCAGGAATAACTTCTTGGGCTTCCCTGCCTCAGAGCTCCAGGCCCGGATTCGAACTTACAATCAGCATTA
  CAACAACCTGCTACGGGGTGCAGTGAGCCAGCGGCTGTATATTCTCCTCCCATTGGACTGTGGGGTGCCT
  GATAACCTGAGTATGGCTGACCCCAACATTCGCTTCCTGGATAAACTGCCCCAGCAGACCGGTGACCGTG
  CTGGCATCAAGGATCGGGTTTACAGCAACAGCATCTATGAGCTTCTGGAGAACGGGCAGCGGGCGGGCAC
  CTGTGTCCTGGAGTACGCCACCCCCTTGCAGACTTTGTTTGCCATGTCACAATACAGTCAAGCTGGCTTT
  AGCCGGGAGGATAGGCTTGAGCAGGCCAAACTCTTCTGCCGGACACTTGAGGACATCCTGGCAGATGCCC
  CTGAGTCTCAGAACAACTGCCGCCTCATTGCCTACCAGGAACCTGCAGATGACAGCAGCTTCTCGCTGTC
  CCAGGAGGTTCTCCGGCACCTGCGGCAGGAGGAAAAGGAAGAGGTTACTGTGGGCAGCTTGAAGACCTCA
  GCGGTGCCCAGTACCTCCACGATGTCCCAAGAGCCTGAGCTCCTCATCAGTGGAATGGAAAAGCCCCTCC
  CTCTCCGCACGGATTTCTCTTGAGACCCAGGGTCACCAGGCCAGAGCCTCCAGTGGTCTCCAAGCCTCTG
  GACTGGGGGCTCTCTTCAGTGGCTGAATGTCCAGCAGAGCTATTTCCTTCCACAGGGGGCCTTGCAGGGA
  AGGGTCCAGGACTTGACATCTTAAGATGCGTCTTGTCCCCTTGGGCCAGTCATTTCCCCTCTCTGAGCCT
  CGGTGTCTTCAACCTGTGAAATGGGATCATAATCACTGCCTTACCTCCCTCACGGTTGTTGTGAGGACTG
  AGTGTGTGGAAGTTTTTCATAAACTTTGGATGCTAGTGTACTTAGGGGGTGTGCCAGGTGTCTTTCATGG
  GGCCTTCCAGACCCACTCCCCACCCTTCTCCCCTTCCTTTGCCCGGGGACGCCGAACTCTCTCAATGGTA
  TCAACAGGCTCCTTCGCCCTCTGGCTCCTGGTCATGTTCCATTATTGGGGAGCCCCAGCAGAAGAATGGA
  GAGGAGGAGGAGGCTGAGTTTGGGGTATTGAATCCCCCGGCTCCCACCCTGCAGCATCAAGGTTGCTATG
  GACTCTCCTGCCGGGCAACTCTTGCGTAATCATGACTATCTCTAGGATTCTGGCACCACTTCCTTCCCTG
  GCCCCTTAAGCCTAGCTGTGTATCGGCACCCCCACCCCACTAGAGTACTCCCTCTCACTTGCGGTTTCCT
  TATACTCCACCCCTTTCTCAACGGTCCTTTTTTAAAGCACATCTCAGATT
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for AK095896 unedited
  AAATTTTGTATACGACGTCACTATAGGGCGGCCGCGAATTCGCACGAGGACATAGACATC
  TGAGGAAAGAATGAGGGAGGGTAAAGGGTGGTGCAGTAAGAGGAGGGGTGGGGAGGGCTT
  TTGGAGGCGCTGCCCCTCCTGGCCTCCTGTACAATGAGAGTGCACTGGACTCTCCATTCT
  CTGGCACCCACACACTGCGGGGGCCAATGACCTGGGTCTCACTCCTGAATCAGGTGGGAG
  ATAGGGTTAGCAGGAATAACTTCTTGGGCTTCCCTGCCTCAGAGCTCCAGGCCCGGATTC
  GAACTTACAATCAGCATTACAACAACCTGCTACGGGGTGCAGTGAGCCAGCGGCTGTATA
  TTCTCCTCCCATTGGACTGTGGGGTGCCTGATAACCTGAGTATGGCTGACCCCAACATTC
  GCTTCCTGGATAAACTGCCCCAGCAGACCGGTGACCATGCTGGCATCAAGGATCGGGTTT
  ACAGCAACAGCATCTATGAGCTTCTGGAGAACGGGCAGCGGGCGGGCACCTGTGTCCTGG
  AGTACGCCACCCCCTTGCAGACTTTGTTTGCCATGTCACAATACAGTCAAGCTGGCTTTA
  GCCGGGAGGATAGGCTTGAGCAGGCCAAACTCTTCTGCCGGACACTTGAGGACATCCTGG
  CAGATGCCCCTGAGTCTCAGAACAACTGCCGCCTCATTGCCTACCAGGAACCTGCAGATG
  ACAGCAGCTTCTCGCTGTCCCAGGAAGTTCTCCGGCACCTGCNGCANGANGAAAANGGAA
  GAGTTACTGTGGGCAGCTTGAAGACCCTCAGCGTGCCCAGTACCTNCACGATGTCCCAAG
  AGCCCTGAGCTCTCATCAGTGGAATGGNAAAAGCCCTNCCTCTCTNACNGATTCTCTTGA
  GACCAGGGTACCAGCCAGAGCCTNCAGTGTCTCCAGCTCTGACTGGGGCTCTCTCATGGC
  TGAATGTCACANACTATTCCTTCAGGGGNCTGCAGGGA
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for AK095896 unedited
  GAATACTTGTTACGCGGCCGCAATCCACGATCGATTTTTTTTTTTTTTTTTTTTTTTTTT
  TTTTTTTTTTTTTTTTTTTTAATCTGGAAAGTGCTTTAAAAAAGACCGTTTAAAAAGGGT
  GGAGTATAAGGAAACCCCAAGTGAAAGGGAGTACTCTATTGGGGTGGGGGTCCCCATACA
  CAACTAGGCTTAAGGGGCCAGGGAAAGAAATGGTGCCAAAATCCTAGAAATAGTCATGAT
  TACCCAAGAATTGCCCGGCCGGAAATTCCATACCACCCTTTATTCTCCCAGGTGGGACCC
  CGGGGAATCAATTCCCCAAACTCATCCTCCTCCTCCTCTCCATTTTTCTGCTGGGGCTCC
  CCAATAATGGAACATTGACCAGGACCCAAGGCCCTAAAGACCCTGTTTACCCCATTGAAA
  GAGTTCGGCGTCCCGGGGACAAGGAAGGGGAAAAGGGGGGCGAGTGCGCTCCTAGACACT
  ATGTAACGCACCACGGACATACCCCAGCACAAGTCCTACACAAACCTACAAGTCTAAATG
  TGACCTACTCCACGCGGAAGAGGGGAACACTGGGAGGAGTGAGAGGAGTGAATCACCAGA
  ATCAGCACACCACAACAGCACGACGAACAAACAGGACAGAGTGACGCGAGCGGTGAACAG
  CAAGGGGCGCGAAACCGCAAACAAAAAAACCCCACACATACAGGAGAAAACGCGAACGAA
  CAAGAGTACAAAACAAAGACACAAGAACAGGAAGAAAAATAAAGTATACCGAGCACGTAG
  CATCGACATTACGGAGTTACGTAAACTTGCCCACATCCTGGTAAGATATGTTTAATATTC
  GGTGATTCCGCAAATTTTCACCCGCCGGGCGGCACAGGCTCCCACCACCCGCCCCGACGA
  ACGGAAAGCAGCGCAGAACGGGCCAA
  
• Restriction Sites: NotI-NotI
• ACCN: AK095896
• Insert Size: 1750 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: AK095896.1
• RefSeq Size: 3200 bp
• RefSeq ORF: 3200 bp
• Locus ID: 340061
• Cytogenetics: 5q31.2
• Protein Pathways: Cytosolic DNA-sensing pathway, RIG-I-like receptor signaling pathway
• Gene Summary: This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]